Can Depression Make Your Period Late?

Depression can cause problems with your period such as a late period or a missed period. This link between mental health and reproductive health makes sense when you consider that nature does everything it can to create favorable conditions for reproduction.

If a woman is chronically stressed, anxious, sad, or upset, she's really not in a physical or emotional position to go through a pregnancy and then take care of and nurture a child. Under these less-than-ideal conditions, the female reproductive system can shut down.

There may also be related reasons why you have menstrual problems when you are depressed. For example, antidepressant medication like Zoloft (sertraline) can also affect your period.

Learn more about how depression affects your period and what your treatment options are.

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How Depression Affects the Menstrual Cycle

The stress hormone cortisol is primarily responsible for changes in a woman's cycle when she's depressed. As cortisol levels rise in response to stress, the hypothalamus, an organ in the brain that plays an important part in regulating the reproductive system, stops sending signals to the ovaries.

Without this signal, ovulation (the monthly release of an egg from the ovary) is either delayed or stopped. The result is a late period or sometimes no period at all.

The medical term for absent periods when there's no pregnancy is amenorrhea, which also can be caused by health issues other than stress including problems with the hypothalamus, the pituitary glands, the ovaries, the uterus, or the vagina.

Pinpointing the Cause of a Missed Period

The first thing you should do if your period is late is to take a pregnancy test, which can be accurate as early as the first day of your missed period. If it's negative and you don't get your period in a few days or you completely skip it that cycle, or if you're having chronic problems with menstruation, make an appointment to see your gynecologist.

Your gynecologist will likely do a repeat pregnancy test. If it's negative, they will move on to some basic evaluations such as asking you about your medical history, doing a pelvic exam, and taking blood samples to check your hormone levels.

Diagnostic Tests

Depending on what these preliminary tests reveal, plus other basic factors such as your age, your doctor may move on to more specific diagnostic methods, which may include:

  • Chromosome evaluation to look for chromosomal variations such as Turner syndrome
  • Genetic testing to see if you have fragile X syndrome
  • A hysteroscopy to examine the inside of your uterus
  • An MRI to check for a pituitary tumor
  • An ultrasound computed tomography (CT) scan or magnetic resonance imaging (MRI) scan to make sure your reproductive organs are normal

Is Depression the Problem?

Amenorrhea caused by chronic stress and depression is called hypothalamic amenorrhea. If you tend to eat more or less than usual when you're depressed and have gained or lost weight, that also could play a part in your menstrual irregularities.

If your doctor has determined that depression is behind your late or missed periods, getting back on track will be a matter of finding an effective way to reduce your stress and treat your depression.

Treatment Options

There are many different ways to treat irregular or absent periods depending on your overall mental health and menstrual irregularities. This can include a wait and see approach (if it's only happened a handful of times), stress management strategies, therapy, and/or prescription medication.

Consult with your gynecologist or mental health care professional to determine the type of treatment plan that's best for your physical and mental health.

Lifestyle Changes

Making an effort to manage stress will reduce your risk of becoming depressed and missing your period. In addition to eating a well rounded diet and practicing good sleep hygiene, try to incorporate stress-lowering activities into your day.

While there isn't a one size fits all option when it comes to stress relief, a few ideas to consider include:

  • Deep breathing
  • Journaling
  • Light exercise (such as walking)
  • Meditation
  • Support groups (online or in-person)
  • Yoga

Therapy

Therapy can help you learn strategies for reducing stress. Some studies have found that cognitive behavioral therapy (CBT) helped restore menstruation in people with hypothalamic amenorrhea. There's also some evidence that CBT can reduce cortisol levels.

Prescription Medication

Taking antidepressants such as Prozac (fluoxetine) or Wellbutrin (bupropion) can be an effective way to relieve symptoms of depression, but they're not right for everyone. In addition to possible side effects, some antidepressants can even cause your period to be late or delayed.

Can Zoloft affect your period?

Zoloft (sertraline) can affect your period. Amenorrhea (the absence of menstruation) is a known side effect of this medication.

You may even be prescribed oral contraceptives to create a regular schedule of withdrawal bleeds, however, combination birth control pills have been linked to depression, so make sure to alert your doctor to your mental health history. It may take some trial and error, but it is possible to get back to feeling normal and your body back to functioning normally.

If you or a loved one are struggling with depression, contact the Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-4357 for information on support and treatment facilities in your area.

For more mental health resources, see our National Helpline Database.

5 Sources
Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Eunice Kennedy Shriver National Institute of Child Health and Human Development.What causes amenorrhea?

  2. Fourman LT, Fazeli PK. Neuroendocrine causes of amenorrhea--an update. J Clin Endocrinol Metab. 2015;100(3):812-24. doi:10.1210/jc.2014-3344

  3. Klein DA, Paradise SL, Reeder RM. Amenorrhea: A systematic approach to diagnosis and management. Am Fam Physician. 2019;100(1):39-48.

  4. Shufelt CL, Torbati T, Dutra E. Hypothalamic amenorrhea and the long-term health consequences. Semin Reprod Med. 2017;35(3):256-262. doi:10.1055/s-0037-1603581

  5. Padda J, Khalid K, Hitawala G, et al. Depression and its effect on the menstrual cycle. Cureus. 2021;13(7):e16532. doi:10.7759/cureus.16532

Additional Reading

By Nancy Schimelpfening
Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.