Abstract
Multiple factors are involved in the elongation stage of transcription regulation to ensure the passing of RNA polymerases while preserving appropriate nucleosome structure thereafter. The recently reported trimeric sub-module of NuA4 histone acetyltransferase complex involved in this process provides more insight into the sophisticated modulation of transcription elongation.
Keywords:
Eaf3; Eaf5; Eaf7; MRG15; MRGBP; NuA4; TINTIN; acetylation; chromatin; transcription elongation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Histone Acetyltransferases / metabolism
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Humans
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Lysine Acetyltransferase 5
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Nucleosomes / metabolism*
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RNA Polymerase II / metabolism*
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins / metabolism
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Transcription Elongation, Genetic*
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Transcription Factors / metabolism*
Substances
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Nucleosomes
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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Histone Acetyltransferases
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KAT5 protein, human
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Lysine Acetyltransferase 5
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NuA4 protein, S cerevisiae
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RNA Polymerase II